Cinnamic acids and derivatives
Aobchem (5-Chloro-2-fluoro-3-(methoxycarbonyl)phenyl)boronic acid | 95% | C8H7BClFO4 | 500mg
(5-Chloro-2-fluoro-3-(methoxycarbonyl)phenyl)boronic acid | 95% | C8H7BClFO4 | 500mg
Medchemexpress LLC 4-Acetoxycinnamic ac 500mg
4-Acetoxycinnamic acid is an acetate ester obtained by the formal condensation of the hydroxy group of trans-4-coumaric acid with acetic acid 4-Acetoxycinnamic acid is a member of cinnamic acids and a member of phenyl acetates 4-Acetoxycinnamic acid derives from a trans-4-coumaric acid[1]
Medchemexpress LLC m-Coumaric acid (Standard) | 588-30-7 | 99.91% | 164.16 | 25 MG
m-Coumaric acid (Standard) is the analytical standard of m-Coumaric acid, intended for research and analytical applications. It is a polyphenol metabolite from caffeic acid, formed by gut microflora, with its amount in human biofluids being diet-dependent. m-Coumaric acid is also a BBB-penetrant metabolite of chlorogenic acid.
- Stimulates the cerebral nerves in vitro.
- Can evoke neurite outgrowth in hippocampal neuronal cells.
- Can promote neuronal differentiation.
- Increases spontaneous locomotor activity in mice by acting on the central nervous system.
- Inhibits the oxidation of L-dopa by epidermis tyrosinase.
- Attenuates non-catalytic protein glycosylation in retinas of diabetic rats.
![Medchemexpress LLC (E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-[(1S)-1-phenylethyl]prop-2-enamide | 133550-37-5 | MFCD00209855 | 97.0% | 308.33 g/mol | C18H16N2O3 | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000211898.png-250.jpg)
Medchemexpress LLC (E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-[(1S)-1-phenylethyl]prop-2-enamide | 133550-37-5 | MFCD00209855 | 97.0% | 308.33 g/mol | C18H16N2O3 | 1 ML
(+)-Tyrphostin B44 is the (+) enantiomer of Tyrphostin AG-835, a small-molecule inhibitor of the epidermal growth factor receptor (EGFR) used in biochemical and cellular research. It is provided as a concentrated solution in DMSO for in vitro assays and is documented with supporting datasheet, certificate of analysis, and safety data information.
- Provides EGFR inhibitory activity useful for signaling and cancer research.
- Supplied as a 10 mM solution in DMSO for ready-to-use preparations.
- High purity suitable for research applications (≈97%).
- Characterized molecular properties for accurate dosing in assays.
- Documentation available to support safe handling and experimental reproducibility.
Selleck Chemical LLC Tyrphostin 9 S2895-25mg
Tyrphostin 9 (SF 6847 RG-50872) is firstly designed as an EGFR inhibitor with IC50 of 460 M but is also found to be more potent to PDGFR with IC50 of 0 5 M
Selleck Chemical LLC Curcumin analog C1
Curcumin analog C1 (Curcumin analog Compound C1) is a potent transcription factor EB (TFEB) activator with promise for the prevention or treatment of Alzheimer s disease
Medchemexpress LLC Tyrphostin 8 | 3785-90-8 | MFCD00020189 | 98.0% | 170.17 g/mol | C10H6N2O | 50 MG
Tyrphostin 8 is a small-molecule research compound that acts as a weak epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor and a more potent inhibitor of the serine/threonine phosphatase calcineurin. Supplied as a solid for laboratory research, it is intended for research use only.
- Small-molecule inhibitor of EGFR and calcineurin (EGFR IC50 560 μM; calcineurin IC50 21 μM).
- High purity: 98.0%.
- Chemical formula C10H6N2O; molecular weight 170.17 g/mol.
- CAS number 3785-90-8.
- Soluble in DMSO at ≥ 100 mg/mL.
- Appearance: light yellow to yellow solid.
- Storage: store at 4°C under nitrogen; in solvent store at -80°C (6 months) or -20°C (1 month).
- For research use only; not for human or clinical applications.
Medchemexpress LLC Tyrphostin AG 528 | 133550-49-9 | MFCD01076474 | 98.0% | 306.32 g·mol^-1 | C18H14N2O3 | 25 MG
Tyrphostin AG 528 is a small-molecule protein tyrosine kinase inhibitor used as a research reagent to probe EGFR and ErbB2 (HER2) signaling pathways. It is supplied as a high-purity solid for biochemical and cellular studies.
- Inhibits EGFR and ErbB2 with reported IC50s of 4.9 μM and 2.1 μM.
- High purity (98.0%) suitable for laboratory research.
- Supplied as a solid, light yellow to yellow in color.
- Molecular weight 306.32 g·mol⁻¹; formula C18H14N2O3.
- Available in small research quantities, including 25 mg packaging.
Medchemexpress LLC Dodeca-2E,4E,8Z,10Z/E-N-tetraenoic acid isobutylamide | 866602-52-0 | 98.5% | 247.38 | C16H25NO | 5mg
Dodeca-2E 4E 8Z 10Z/E-N-tetraenoic acid isobutylamide is a brain-penetrant substance and the main alkamide in Echinacea preparations which might be used for research of common cold and various upper respiratory infections[1]
Apexbio Technology LLC (E,E)-Bisdemethoxycurcumin 33171-05-0 5mg
(E E)-Bisdemethoxycurcumin (CAS 33171-05-0) is a naturally derived curcuminoid and a structural analog within the demethoxycurcumin class Research demonstrates that this compound modulates multiple inflammatory signaling pathways and alters the expression of various inflammatory mediators It has been shown to induce cell cycle arrest promote apoptosis in cancer cells and inhibit proliferation-related pathways (E E)-Bisdemethoxycurcumin is widely utilized in studies investigating the molecular mechanisms of inflammation tumor cell biology and the pharmacological properties of curcuminoid derivatives
Apexbio Technology LLC Tyrphostin A1 2826-26-8 10mg
Tyrphostin A1 (CAS 2826-26-8) is a small molecule inhibitor targeting tyrosine kinase activity specifically involved in disrupting intracellular signaling pathways in immune cells It has been shown to interfere with CD40 ligand-induced signaling resulting in suppressed interleukin-12 (IL-12) secretion by macrophages and reduced differentiation of antigen-induced T helper 1 (Th1) cells Tyrphostin A1 is widely utilized in studies investigating cell-to-cell signaling immune response modulation and the mechanisms underlying inflammatory processes particularly in the context of autoimmune disease models
TARGETMOL CHEMICALS INC Tipifarnib S enantiomer 5MG
Also available in 1 mL, 1 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg and bulk. Please contact Fisher for quotes. Tipifarnib S enantiomer ((S)-(-)-R-115777) is the S-enantiomer of Tipifarnib. Tipifarnib is a potent and specific farnesyltransferase inhibitor (IC50 0.6 nM). Purity 99.05%
![Medchemexpress LLC Propanedinitrile, 2-[(3,4-dihydroxy-5-nitrophenyl)methylene]- | 116313-73-6 | 98.7% | 231.16 g·mol⁻¹ | C10H5N3O4 | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000245870.png-250.jpg)
Medchemexpress LLC Propanedinitrile, 2-[(3,4-dihydroxy-5-nitrophenyl)methylene]- | 116313-73-6 | 98.7% | 231.16 g·mol⁻¹ | C10H5N3O4 | 50 MG
Tyrphostin AG 1288 is a research-grade small-molecule tyrosine kinase inhibitor reported to inhibit ICAM1 expression and TNFα-mediated cytotoxicity in vitro. The compound is supplied with analytical characterization and recommended storage conditions to support reliable laboratory use.
- Potent tyrosine kinase inhibitor in biochemical and cellular assays.
- Inhibits ICAM1 expression in cell-based studies.
- Reduces TNFα-mediated cytotoxicity in vitro.
- High purity suitable for research applications (≈98.7%).
- Available in multiple small pack sizes for laboratory workflows.
- Stable when stored under recommended conditions for powder and solutions.
AdipoGen Curcumin
Chemical. CAS 458-37-7. Formula C21H20O6. MW 368.38. Curcumin is the major yellow pigment in turmeric and curry and has antioxidant, anti-inflammatory, neuroprotective, cardioprotective, antidiabetic, antiviral, antibacterial, antifungal, chemopreventive and antitumor activities. It interferes with multiple cell signaling pathways, including cell cycle cyclin D1 and cyclin E, apoptosis activation of caspases and down-regulation of anti-apoptotic gene products, proliferation HER-2, EGFR and AP-1, survival PI3K/AKT pathway, invasion MMP-9 and adhesion molecules, angiogenesis VEGF, metastasis CXCR-4, tumorigenesis and development Shh, Gli, metabolism PPARgamma, Nrf2, epigenetics HDACs, HATs, DNA methyltransferase I and microRNAs and inflammation NLRP3, TLR4, NF-kappaB, TNF, IL-6, IL-1, COX-2 and 5-LOX.